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Huntington’s disease successfully treated for first time

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James GallagherHealth and science correspondent

imageBBC/Fergus Walsh

One of the cruellest and most devastating diseases – Huntington’s – has been successfully treated for the first time, say doctors.

The disease runs through families, relentlessly kills brain cells and resembles a combination of dementia, Parkinson’s and motor neurone disease.

An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients.

It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of “good quality life”, Prof Sarah Tabrizi told BBC News.

The new treatment is a type of gene therapy given during 12 to 18 hours of delicate brain surgery.

The first symptoms of Huntington’s disease tend to appear in your 30s or 40s and is normally fatal within two decades – opening the possibility that earlier treatment could prevent symptoms from ever emerging.

Prof Tabrizi, director of the University College London Huntington’s Disease Centre, described the results as “spectacular”.

“We never in our wildest dreams would have expected a 75% slowing of clinical progression,” she said.

None of the patients who have been treated are being identified, but one was medically retired and has returned to work. Others in the trial are still walking despite being expected to need a wheelchair.

Treatment is likely to be very expensive. However, this is a moment of real hope in a disease that hits people in their prime and devastates families.

imageBBC/Fergus Walsh Jack May-Davis is smiling and is wearing a pale blue shirt. He is standing on a street with green hedges and a row of cars blurred in the backgroundBBC/Fergus Walsh

Huntington’s runs through Jack May-Davis’ family. He has the faulty gene that causes the disease, as did his dad, Fred, and his grandmother, Joyce.

Jack said it was “really awful and horrible” watching his dad’s inexorable decline.

The first symptoms appeared in Fred’s late 30s, including changes in behaviour and the way he moved. He eventually needed 24/7 palliative care before he died at the age of 54, in 2016.

Jack is 30, a barrister’s clerk, newly engaged to Chloe and has taken part in research at UCL to turn his diagnosis into a positive.

But he’d always known he was destined to share his father’s fate, until today.

Now he says the “absolutely incredible” breakthrough has left him “overwhelmed” and able to look to a future that “seems a little bit brighter, it does allow me to think my life could be that much longer”.

imageMay-Davis family An old family photograph of Fred resting his head on his hand with a young Jack in his lapMay-Davis family

Huntington’s disease is caused by an error in part of our DNA called the huntingtin gene.

If one of your parents has Huntington’s disease, there’s a 50% chance that you will inherit the altered gene and will eventually develop Huntington’s too.

This mutation turns a normal protein needed in the brain – called the huntingtin protein – into a killer of neurons.

The goal of the treatment is to reduce levels of this toxic protein permanently, in a single dose.

The therapy uses cutting edge genetic medicine combining gene therapy and gene silencing technologies.

imageGraphical illustration of how the therapy works separated into four tiles. The first shows a spindly brain cell with a zoomed-in section showing a DNA double helix in blue with a red section denoting the mutated DNA and the build up of toxic protein, also red, inside the brain cell. Tile 2 shows two neurons and hexagonal viruses with a purple line in the middle. Tile 3 shows a close-up of the neurons from before with the viruses inside and releasing their purple squiggly line. Tile 4 goes back to the same zoomed-in view of a neuron, but this time the purple squiggles are sticking to the previous genetic code so there is less toxic protein being made, represented by it being shaded out.

It starts with a safe virus that has been altered to contain a specially designed sequence of DNA.

This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions – the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery.

The virus then acts like a microscopic postman – delivering the new piece of DNA inside brain cells, where it becomes active.

This turns the neurons into a factory for making the therapy to avert their own death.

The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells’ DNA for building mutant huntingtin.

This results in lower levels of mutant huntingtin in the brain.

imageUCLH The images show two cross sections of the human brain in black and white side- by-side. You can see the semi-circular outline of the skull. Inside is the folded brain matter. The key difference between the two images is the greater amount of dark space on the right demonstrating where brain tissue has died.UCLH

Results from the trial – which involved 29 patients – have been released in a statement by the company uniQure, but have not yet been published in full for review by other specialists.

The data showed that three years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life.

The data also shows the treatment is saving brain cells. Levels of neurofilaments in spinal fluid – a clear sign of brain cells dying – should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.

“This is the result we’ve been waiting for,” said Prof Ed Wild, consultant neurologist at the National Hospital for Neurology and Neurosurgery at UCLH.

“There was every chance that we would never see a result like this, so to be living in a world where we know this is not only possible, but the actual magnitude of the effect is breathtaking, it’s very difficult to fully encapsulate the emotion.”

He said he was “a bit teary” thinking about the impact it could have on families.

The treatment was considered safe, although some patients did develop inflammation from the virus that caused headaches and confusion that either resolved or needed steroid treatment.

Prof Wild anticipates the therapy “should last for life” because brain cells are not replaced by the body in the same manner as blood, bone and skin are constantly renewed.

Approximately 75,000 people have Huntington’s disease in the UK, US and Europe with hundreds of thousands carrying the mutation meaning they will develop the disease.

UniQure says it will apply for a licence in the US in the first quarter of 2026 with the aim of launching the drug later that year. Conversations with authorities in the UK and Europe will start next year, but the initial focus is on the US.

Dr Walid Abi-Saab, the chief medical officer at uniQure, said he was “incredibly excited” about what the results mean for families, and added that the treatment had “the potential to fundamentally transform” Huntington’s disease.

However, the drug will not be available for everyone due to the highly complex surgery and the anticipated cost.

“It will be expensive for sure,” says Prof Wild.

There isn’t an official price for the drug. Gene therapies are often pricey, but their long-term impact means that can still be affordable. In the UK, the NHS does pay for a £2.6m-per-patient gene therapy for haemophilia B.

Prof Tabrizi says this gene therapy “is the beginning” and will open the gates for therapies that can reach more people.

She paid tribute to the “truly brave” volunteers who took part in the trial, saying she was “overjoyed for the patients and families”.

She is already working with a group of young people who know they have the gene, but don’t yet have symptoms – known as stage zero Huntington’s – and is aiming to do the first prevention trial to see if the disease can be significantly delayed or even stopped completely.

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How luxury brands are tapping into the Labubu craze

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  • Labubu dolls have become a $27 status symbol. Now, high-end brands are testing whether fans are willing to pay luxury prices for crystal-encrusted Labubus or $2,500 bags with the ugly-cute monster.
  • While Labubu mania is new, luxury labels have capitalized on cuteness with other characters from Snoopy to Totoro.
  • Luxury industry experts told CNBC why these high-end character collaborations are here to stay.
A brown Louis Vuitton Monogram coated-canvas mini top-handle bag with tan vachetta leather rolled handles and a yellow-and-orange pumpkin motif is carried with two Labubu plush bag charms during Copenhagen Fashion Week, on August 07, 2025 in Copenhagen, Denmark.
Edward Berthelot | Getty Images Entertainment | Getty Images

Labubu dolls have emerged as a must-have accessory in luxury fashion, with celebrities like Blackpink’s Lisa pairing the toys with Louis Vuitton and Hermès bags.

The coveted blind box toys — collectible plushes that look like a rabbit-esque monster with jagged teeth — are a relatively inexpensive status symbol at $27, though they routinely sell at a premium on the resale market. Now, high-end brands are testing whether Labubu fans are willing to pay luxury price points.

In June, a collection of 14 customized Labubus dressed in designs by Carhartt and Japanese brand Sacai raised $337,500 at auction with the top lot fetching $31,250. At the recent U.S. Open, tennis champion Naomi Osaka touted crystal-encrusted Labubus that cost some $500 from A-Morir. Due to high demand, the “Lablingblings” take four to six weeks for delivery, according to the New York custom eyewear and accessories maker.

Next up, the dolls are teaming up with Parisian maison Moynat. In just over two weeks, the fashion house is releasing a collection of handbags, leather accessories and, of course, bag charms that feature Labubus and two other characters by artist Kasing Lung, the Hong Kong Dutch artist who created Labubu. Moynat’s signature monogrammed canvas totes start at $2,150 and bag charms retail for $450.

While Labubu mania is new, high-end brands from Tiffany to Loewe are increasingly featuring characters like Pikachu and Totoro to court younger and digitally savvy customers. Done right, these collaborations not only generate hype, but pay off.

Omega’s “Silver Snoopy” Speedmaster watches are coveted collectors items, with its 2015 model, originally priced at $7,350, worth nearly $38,000 on the secondary market, according to market data provider WatchCharts. Jimmy Choo’s two collections with Sailor Moon, with the most recent one released in October, quickly sold out. Some brands create their own endearing characters, like Louis Vuitton dropping a line of “Louis Bear” stuffed animal bag charms in July.

Boston Consulting Group’s Jeff Lindquist told CNBC that these collaborations have picked up in popularity in the past decade to target customers who can afford high-end items but aren’t fashion-obsessed.

“Cute is not trivial. It is strategic,” said Lindquist, partner at BCG, where he advises luxury fashion and beauty brands. “It performs incredibly well on platforms like TikTok where virality and cultural relevance are what drives the visibility and the desirability of the brands.”

Moynat’s Bertrand Le Gall said the collaboration with Lung is a way for the 176-year-old maison to stay culturally relevant and resonate with customers.

“The cute elements, even though they have this deep artistic value and this deeper design value, I think we are playing on the emotional value of of everything,” said Le Gall, the image and communication director. “This emotional value is so important when it comes to a house like ours with a very long legacy and historical background.”

‘Element of cute’

French maison Moynat has partnered with Kasing Lung, the artist behind Labubu, on a limited collection of handbags and accessories.
Courtesy of Moynat

Gen Z customers are especially looking for emotional value, according to Lindquist. Many have pulled back their spending as they have felt the effect of inflation and see less value in traditional luxury goods.

“Gen Z sees luxury less as craftmanship and artistry and status and more as mirrors to their identities and their beliefs,” he said.

Daniel Langer, professor of luxury strategy at Pepperdine University, compared the draw of characters to that of celebrities.

“The characters stand for something, and those characters also have a fan base,” he said. “There’s people who really love them.”

But to drum up hype, collaborations, like Labubu blind boxes, should tap into the thrill of the hunt, he added. In the case of the Moynat collection, it will not retail online and only sell at one Moynat boutique at a time from Oct. 11 to early 2026

“Everyone who has a Labubu can tell a personal story about how they got them,” said Langer, who described buying an authentic but reasonably priced one for his daughter as “quite an undertaking.”

Naomi Osaka of Japan poses for a photo with her Labubu after defeating Greet Minnen of Belgium in the first round on Day 3 of the US Open at USTA Billie Jean King National Tennis Center on August 26, 2025 in New York City.
Robert Prange | Getty Images Sport | Getty Images

Capsule collections give brands the opportunity to experiment with new looks and broaden their audience, according to consultant Alexander Thiel.

“Collabs give you a license in the eye of the consumer to do something that otherwise for your brand would be unexpected and therefore opening it up to new audience,” said Thiel, who led McKinsey’s consumer packaged goods and retail business in Switzerland until September.

That said, brands run the risk of alienating their core audience, according to Thomai Serdari, marketing professor at New York University. For instance, while Loewe’s three collections with Studio Ghibli were successful, it would not have made sense for a more traditional brand to sell Totoro purses or wallets with the mouse from “Spirited Away.”

“In the case of Loewe, it made perfect sense, because they had an intentional shift from something very low-key and very traditional quiet luxury before the acquisition by LVMH,” she said. “Then within the portfolio of LVMH, they became the creative kid, the smaller brand that experiments and is playful.”

She also cautioned against trend chasing, saying a phenomenon like Labubu mania can “collapse as quickly as it was built.”

Shares of Pop Mart, the manufacturer of Labubu dolls, have sunk by roughly 21% since peaking in late August on analyst fears that the frenzy is fading. However, the stock is still up nearly 200% year to date, and some analysts are still bullish on Pop Mart’s prospects. HSBC’s Lina Yan noted that Labubu only started actively collaborating with brands like Coca-Cola in 2024.

“The supply and demand of Labubus won’t tilt 180 degrees,” Yan wrote. “We believe it is too early to call for a peak.”

It’s too soon to judge Labubu’s staying power. But Thiel said he thinks that the Labubu craze and influx of bag charms like Louis Bear indicate consumers are looking for innocent distractions from economic anxiety.

“We see that there’s a lot of anxiety and a lot of uncertainty, and not only in the parts of the socioeconomic demographic that are struggling economically, but across all levels,” he said. “I think it’s not surprising that there’s a bit of clinging to wholesomeness and that element of cute. I think it speaks to something deeper.”

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Urgent review ordered into asylum seeker taxi costs after BBC investigation

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Sue Mitchell and

Rachel Muller-Heyndyk

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The home secretary has ordered an urgent review into the use and cost of taxis to transfer asylum seekers from their hotels to appointments.

The move by Shabana Mahmood follows a BBC investigation that found some migrants have to travel long distances on journeys costing hundreds of pounds.

One asylum seeker told the BBC he had taken a 250-mile journey to visit a GP, with the driver telling him the cost to the Home Office was £600.

Asylum seekers are issued with a bus pass for one return journey per week, but for any other necessary travel, such as a doctor’s appointment, taxis are called.

The BBC asked the government how much it spends on taxi travel for asylum seekers via a Freedom of Information Act request, but the Home Office said it does not keep these figures.

The File on Four investigation reported that asylum seekers must show proof of an upcoming appointment at the reception desk of their hotel, where a taxi is booked on an automated system. Public transport or walking is not presented as an option.

This can result in some unusually long journeys and others that are unusually short.

For instance, when migrants move between hotels, they sometimes keep the same NHS doctors – especially for GP referrals.

Work and Pensions Secretary Pat McFadden told BBC Radio 4’s Today programme he agreed that there should be an investigation into how the system works.

“I’m not surprised that this was a feature that caught people’s eye”, he said.

On Tuesday, housing minister Matthew Pennycook told the Today programme it was “questionable” that asylum seekers needed to take such long taxi journeys and said the government would “look into those cases”.

He added that asylum seekers were not “ordinary citizens just jumping on a bus”.

Shadow home secretary Chris Philp, said: “Every £600 taxi ride for migrants is money that should be paying for British patients to see their GP or for ambulances to turn up on time. This is why people feel the system is rigged against them.

“Labour are writing a blank cheque for illegal immigration while services for hard-working families are strained.”

Reform UK MP Lee Anderson said: “This is likely just the tip of the iceberg and yet another example of how the Tories and Labour have spent billions supporting migrants at the expense of our own people.”

A spokesperson for the Liberal Democrats called the taxi costs “a ridiculous waste of taxpayer money and shows exactly why the government must take the asylum crisis seriously and end hotel use”.

The BBC went into four hotels housing asylum seekers, as part of its investigation, uncovering cramped living conditions, illegal working, and fire alarms covered with plastic bags, as residents secretly cooked meals over electric hobs in bathrooms.

The BBC found:

  • Smoke alarms covered with plastic bags as residents cooking meals used electric hobs in bathrooms
  • A 12-year-old girl living in a hotel who had spent three-quarters of her life in the asylum system. “Once we get settled in a place, then they move us,” she said
  • Some asylum seekers saying they had no choice but to work illegally for as little as £20 a day to pay off debts to people smugglers

The issue of asylum seekers in hotels has become a heated political issue attracting protests and a legal challenge by an Essex council attempting to close a hotel in its district.

The government plans to end the use of hotels for housing asylum seekers.

In August, asylum seekers told the BBC that protests outside hotels left them feeling isolated and anxious.

They emphasised that they did not choose to live in hotels and struggled in “damp and dirty” conditions.

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Food price inflation ‘shows no signs of abating’, says Bank of Ireland

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Irish food price inflation is not “showing signs of abating” in the near future, analysts from Bank of Ireland have said, due to global factors including weather and supply chain disruption.

In its latest outlook report for the food and beverage sector, the bank said the sector saw “robust” export growth in the first half of the year, totalling €9.4 billion, an increase of 15 per cent from the January to June period last year.

Still, the industry is facing steep challenges, including a “high cost base” and rising food and ingredient prices.

Food price inflation in Ireland rose to a 20-month high of 5 per cent in August, according to the Central Statistics Office’s latest flash estimate for the harmonised index of consumer prices.

Earlier this week, consumer data company Worldpanel by Numerator said that grocery prices rose by 6 per cent over the summer months, with the rate of increase now more than three times higher than the general rate of consumer price inflation within the economy.

In Wednesday’s report, Lucy Ryan, head of food and beverage at Bank of Ireland, said that food price inflation is unlikely to abate in the near future.

“Food Inflation and climate change are of concern, and whilst the food supply chain is carefully controlling the high cost-base, consumer food and beverage prices will remain high,” she said.

Despite a decline in cereals, dairy and sugar prices, a global index of food prices rose by 1.6 per cent between June and July, largely due to higher meat and oil prices, according to the report.

Cocoa prices have moderated somewhat in recent months, but “with low global stock levels, it is likely cocoa prices will stay high”.

Global coffee prices, meanwhile, “have risen significantly”, Bank of Ireland said.

“Anticipated prices show high prices are likely to continue,” Ms Ryan noted. “This is driven by yields affected by extreme weather, disrupted supply chains, tariffs affecting supply routes, and political instability.”

On a more positive note for Irish food exporters, Ms Ryan said the imposition of a 15 per cent tariff on EU goods imported into the US has “brought some level of certainty” for the sector after months of speculation about US trade policy.

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